Synthetic and biological studies on the spiro-mamakone system.
نویسندگان
چکیده
An exploration of the chemistry of the spiro-mamakone system, exemplified by the cytotoxic, fungal metabolite spiro-mamakone A, is presented. The first reported synthesis of the spiro-mamakone carbon skeleton was achieved, as well as the synthesis of a variety of closely related analogues of the natural product. Biological testing of the synthetic analogues generated a structure-activity profile for the natural product, establishing the importance of the enedione moiety to biological activity.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 6 20 شماره
صفحات -
تاریخ انتشار 2008